Evolution & genetics of inflammatory conditions
Understanding how pathogen-driven selection shaped modern inflammatory conditions, and which risk variants remain functional in immune cells.
Read more →EvolBioMed · Saint Petersburg · Tartu
Evolutionary immunogenetics of modern humans
We are interested in understanding the evolutionary history of modern humans and how this shaped the diversity of immune phenotypes observed in contemporary populations.
Our team spans research groups at the University of Tartu in Estonia (people at cGEM) and Saint Petersburg State University in Russia, in collaboration with researchers at ITMO University in Saint Petersburg and Bashkir State Medical University in Ufa.
What we work on
Three connected questions drive the group: how selection acting on immune genes shaped present-day disease risk, how human demographic history structured genetic variation, and which host and microbial factors determine the outcome of tuberculosis infection.
Human population genetics
Understanding neutral and adaptive evolution of modern human populations, including rare-variant history and ancestry reconstruction.
Read more →Genetic susceptibility to tuberculosis
Focus on the host: genetic susceptibility to tuberculosis, treatment outcome, and the gut microbiome and resistome during chemotherapy.
Read more →News
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Milyausha Yunusbaeva's project funded by the Russian Science Foundation “The impact of long-term multicomponent chemotherapy on the gut microbiome and resistome of tuberculosis patients”.
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Anastasiya Kislova defended her MSc thesis Congratulations from the whole group.
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Dina Sabirova defended her MSc thesis Many thanks to Mikhail Rayko, who supervised the MSc project.
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Grigory Sergeev, Anna Bogdanova and Darya Terentyeva defended their MSc theses Congratulations to all three.
Where we are
Saint Petersburg State University
Department of Genetics and Biotechnology — the oldest department of genetics in Russia.
University of Tartu
Collaboration with the Centre for Genomics, Evolution and Medicine (cGEM) and the Institute of Genomics / Estonian Biobank.
Partners
ITMO University (SCAMT Institute), Saint Petersburg; Bashkir State Medical University, Ufa.
Get in touch. For collaborations, data requests or student positions, write to yunusbb@gmail.com. Dataset accessions and dissemination material are listed on the Resources page.